Metronidazole for Amoebiasis: A tale of more than half a century

Metronidazole has many unique properties such as possessing antibacterial well anti-protozoal activity, very minimal resistance rate, acceptable safety profile and market longevity. remained the recommended drug in treatment of any form amoebiasis caused by Entamoeba histolytica since its inception almost half a c entury ago. Anaphylaxis which limits use agents is hardly reported with metronidazole accounting for favourable profile. Owing to low-cost, it considered affordable economically accessible developing countries are mainly affected amoebiasis. Its pharmacokinetic asset drawback. For example, good bioavailability tissue penetration allows be used oral dosage indications responsible efficacy extra-intestinal However, inhibition hepatic metabolizing enzymes some significant interactions, disulfiram like effect alcohol. Unlike other antimicrobial were discovered much later, withstood problem resistance. Even longer acting have been developed recent past, remains first choice documenting high cure rate need modalities.